INFLUENCE OF THE INCORPORATION OF (S)-9-(3,4-DIHYDROXY-BUTYL)ADENINE ON THE ENZYMATIC STABILITY AND BASE-PAIRING PROPERTIES OF OLIGODEOXYNUCLEOTIDES

被引：47

作者：

AUGUSTYNS, K

VANAERSCHOT, A

VANSCHEPDAEL, A

URBANKE, C

HERDEWIJN, P

机构：

[1] REGA INST,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM

[2] HANOVER MED SCH,W-3000 HANNOVER 61,GERMANY

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 10期

关键词：

D O I：

10.1093/nar/19.10.2587

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.

引用

页码：2587 / 2593

页数：7

共 21 条

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