A 6.5-MB YEAST ARTIFICIAL CHROMOSOME CONTIG INCORPORATING 33 DNA MARKERS ON THE HUMAN X-CHROMOSOME AT XQ122

被引：31

作者：

VETRIE, D

KENDALL, E

COFFEY, A

HASSOCK, S

COLLINS, J

TODD, C

LEHRACH, H

BOBROW, M

BENTLEY, DR

HARRIS, A

机构：

[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[2] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

来源：

GENOMICS | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome, (C) 1994 Academic Press, Inc.

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页码：42 / 47

页数：6

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