THE HUMORAL IMMUNE-RESPONSES OF PATIENTS BITTEN BY THE SNAKE BOTHROPS-JARARACA (JARARACA)

被引：9

作者：

DOMINGOS, MO ^{[1
]}

CARDOSO, JL ^{[1
]}

DASILVA, AMM ^{[1
]}

MOTA, I ^{[1
]}

机构：

[1] INST BUTANTAN,IMMUNOL RES & TRAINING CTR,AV VITAL BRASIL 1500,BR-05504 SAO PAULO,BRAZIL

来源：

TOXICON | 1990年 / 28卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0041-0101(90)90262-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The isotype and specificity of antibodies produced by patients bitten by B. jararaca and submitted to serum therapy were studied. The IgG anti-B. jararaca antibodies have large individual dispersion, starting to appear 10 days after the first bite and increasing to at least 80 days after the bite. IgM antibodies appeared sooner than IgG antibodies but disappeared about 20 days after the bite. Secondary responses induced by an additional bite were characterized by a fast and higher IgG antibody response with no apparent change in the IgM antibody. The immunoblotting tests showed that the specificity of human anti-B. jararaca antibodies is heterogeneous, each patient recognizing different fractions in the B. jararaca venom. © 1990.

引用

页码：723 / 726

页数：4

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