NEUTRALIZATION EPITOPES OF HUMAN RHINOVIRUS TYPE-2

被引：47

作者：

APPLEYARD, G ^{[1
]}

RUSSELL, SM ^{[1
]}

CLARKE, BE ^{[1
]}

SPELLER, SA ^{[1
]}

TROWBRIDGE, M ^{[1
]}

VADOLAS, J ^{[1
]}

机构：

[1] WELLCOME BIOTECHNOL LTD,DEPT VIROL,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-6-1275

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Cross-resistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type 14, although there are also substantial differences. The third site has not been described previously.

引用

页码：1275 / 1282

页数：8

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