STIMULATION OF LOCOMOTOR-ACTIVITY BY INTRAACCUMBENS AMPA IS NOT INHIBITED BY NEONATAL 6-HYDROXYDOPAMINE-INDUCED LESIONS

被引：13

作者：

BOLDRY, RC ^{[1
]}

LAYER, RT ^{[1
]}

WALLACE, LJ ^{[1
]}

URETSKY, NJ ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL PHARM, DEPT PHARMACOL, COLUMBUS, OH 43210 USA

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 02期

关键词：

AMPHETAMINE; EXCITATORY AMINO ACID; AMPA; DOPAMINE; LOCOMOTOR ACTIVITY; 6-HYDROXYDOPAMINE;

D O I：

10.1016/0304-3940(92)90930-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of dopamine in the hypermotility responses to amphetamine s.c. or AMPA injected into the nucleus accumbens was evaluated in adult rats depleted of dopamine as neonates with 6-hydroxydopamine. The hypermotility response to amphetamine was markedly inhibited in the lesioned animals, while that to AMPA was enhanced. In addition, the hypermotility produced by AMPA in these rats was not inhibited by sulpiride +SCH-23390; however, it was inhibited completely by alpha-methyl-p-tyrosine. These results suggest that the hypermotility produced by AMPA requires endogenous dopamine, but is mediated by a different mechanism than that produced by amphetamine.

引用

页码：265 / 269

页数：5

共 27 条

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