ABNORMAL FACILITATIVE GLUCOSE TRANSPORTER GENE-EXPRESSION IN HUMAN ISLET-CELL TUMORS

被引：37

作者：

SEINO, Y

YAMAMOTO, T

INOUE, K

IMAMURA, M

KADOWAKI, S

KOJIMA, H

FUJIKAWA, J

IMURA, H

机构：

[1] KYOTO UNIV, FAC MED, DEPT METAB & CLIN NUTR, KYOTO 606, JAPAN

[2] KYOTO UNIV, FAC MED, DEPT MED 2, KYOTO 606, JAPAN

[3] SUZUKU UNIV MED SCI & TECHNOL, FAC HLTH SCI, DIV CLIN NUTR & METAB, SUZUKU 510, JAPAN

[4] SHIMADA CITY HOSP, SHIMADA 427, JAPAN

[5] KITANO HOSP, OSAKA 530, JAPAN

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1993年 / 76卷 / 01期

关键词：

D O I：

10.1210/jc.76.1.75

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our previous studies have shown that increased expression of GLUT1/erythrocyte and GLUT3/brain type glucose transporter genes in human tumors is associated with cellular transformation. We have now determined the levels of messenger RNAs (mRNAs) encoding these two glucose transporter isoforms as well as that of GLUT2/liver isoform in insulin-, glucagon-, and gastrin-secreting islet cell tumors. Northern blot analysis and reverse transcriptase-polymerase chain reaction revealed the presence of GLUT1 and GLUT3 mRNA in all human islet cell tumors and normal islets examined. In contrast, GLUT2 mRNA, which is present at high levels in normal islets, was not detected in insulinomas or other types of islet cell tumors. These results imply that GLUT1 and GLUT3 are primarily responsible for glucose uptake by these tumors.

引用

页码：75 / 78

页数：4

共 24 条

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