PHYSOSTIGMINE AMELIORATES THE DELUSIONS OF ALZHEIMERS-DISEASE

被引：103

作者：

CUMMINGS, JL

GORMAN, DG

SHAPIRA, J

机构：

[1] W LOS ANGELES VET AFFAIRS MED CTR, NURSING SERV, LOS ANGELES, CA USA

[2] UNIV CALIF LOS ANGELES, SCH MED, CTR ALZHEIMERS DIS, LOS ANGELES, CA USA

[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT NEUROL, LOS ANGELES, CA USA

[4] UNIV CALIF LOS ANGELES, SCH MED, DEPT PSYCHIAT & BIOBEHAV SCI, LOS ANGELES, CA USA

[5] UNIV CALIF LOS ANGELES, SCH NURSING, LOS ANGELES, CA USA

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 07期

关键词：

ALZHEIMERS DISEASE; DELUSIONS; PHYSOSTIGMINE; HALOPERIDOL; ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE INHIBITOR;

D O I：

10.1016/0006-3223(93)90009-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) patients frequently manifest delusions, and the cholinergic deficiency of AD may contribute to this aspect of the psychopathology of the disorder. In a double-blind, crossover study involving two patients, we compared the antidelusional efficacy of physostigmine, an acetylcholinesterase inhibitor, with haloperidol, a widely used neuroleptic agent. Physostigmine ameliorated the delusions and produced fewer side effects. These preliminary observations suggest that the cholinergic deficiency contributes to the occurrence of delusions in AD and cholinergic therapy may have a role in the treatment of the delusional symptoms.

引用

页码：536 / 541

页数：6

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