THE GENOMIC ORGANIZATION OF HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR

被引：75

作者：

GUO, DF

FURUTA, H

MIZUKOSHI, M

INAGAMI, T

机构：

[1] Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT(1) receptor was investigated. Comparison of the genomic DNA and cDNA sequences revealed that it consists of at least five exons. The length of the AT(1) receptor gene is greater than 55 kb, and the size of the exons ranges from 59 to 2,014 base pairs. Four of the exons encoded 5'-untranslated sequences. Multiple transcription initiation sites were observed by primer extension experiment. The promoter function was examined by using luciferase as a report gene in transfected human vascular smooth muscle cells. (C) 1994 Academic Press, Inc.

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页码：313 / 319

页数：7

相关论文

共 13 条

[1] CLONING AND CHARACTERIZATION OF A HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR [J].

BERGSMA, DJ ;

ELLIS, C ;

KUMAR, C ;

NUTHULAGANTI, P ;

KERSTEN, H ;

ELSHOURBAGY, N ;

GRIFFIN, E ;

STADEL, JM ;

AIYAR, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (03) :989-995

[2]

BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025

[3] GENETIC-ANALYSIS OF THE HUMAN TYPE-1 ANGIOTENSIN-II RECEPTOR [J].

CURNOW, KM ;

PASCOE, L ;

WHITE, PC .

MOLECULAR ENDOCRINOLOGY, 1992, 6 (07) :1113-1118

[4] PROMOTERS FOR HOUSEKEEPING GENES [J].

DYNAN, WS .

TRENDS IN GENETICS, 1986, 2 (08) :196-197

[5] MOLECULAR-CLONING AND SEQUENCING OF THE GENE ENCODING HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR [J].

FURUTA, H ;

GUO, DF ;

INAGAMI, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (01) :8-13

[6]

GUO DF, IN PRESS BIOCH BIOPH

[7] CLONING, EXPRESSION, AND CHARACTERIZATION OF A GENE ENCODING THE HUMAN ANGIOTENSIN-II TYPE-1A RECEPTOR [J].

MAUZY, CA ;

HWANG, O ;

EGLOFF, AM ;

WU, LH ;

CHUNG, FZ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 186 (01) :277-284

[8] TRANSCRIPTIONAL SELECTIVITY OF VIRAL GENES IN MAMMALIAN-CELLS [J].

MCKNIGHT, S ;

TJIAN, R .

CELL, 1986, 46 (06) :795-805

[9] NOVEL SITES OF EXPRESSION OF FUNCTIONAL ANGIOTENSIN-II RECEPTORS IN THE LATE GESTATION FETUS [J].

MILLAN, MA ;

CARVALLO, P ;

IZUMI, S ;

ZEMEL, S ;

CATT, KJ ;

AGUILERA, G .

SCIENCE, 1989, 244 (4910) :1340-1342

[10] THE ANGIOTENSIN-II RECEPTOR AND THE ACTIONS OF ANGIOTENSIN-II [J].

PEACH, MJ ;

DOSTAL, DE .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 16 :S25-S30