INCREASED NITRIC-OXIDE IN THE EXHALED AIR OF PATIENTS WITH DECOMPENSATED LIVER-CIRRHOSIS

被引：98

作者：

MATSUMOTO, A ^{[1
]}

OGURA, K ^{[1
]}

HIRATA, Y ^{[1
]}

KAKOKI, M ^{[1
]}

WATANABE, F ^{[1
]}

TAKENAKA, K ^{[1
]}

SHIRATORI, Y ^{[1
]}

MOMOMURA, S ^{[1
]}

OMATA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 2, BUNKYO KU, TOKYO 113, JAPAN

来源：

ANNALS OF INTERNAL MEDICINE | 1995年 / 123卷 / 02期

关键词：

D O I：

10.7326/0003-4819-123-2-199507150-00005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine if nitric oxide output in exhaled air is increased in patients with liver cirrhosis. Design: Cross-sectional study. Setting: A university hospital. Patients: 50 patients with liver cirrhosis, 6 patients with chronic hepatitis, and 15 healthy controls. Measurements: Nitric oxide in exhaled air was measured using a chemiluminescence analyzer. Cardiac index was determined using echocardiography. Results: Patients with decompensated liver cirrhosis had higher levels of exhaled nitric oxide output (Child C patients, 190 +/- 11 nL/min per m(2) body surface area) than controls (97 +/- 8 nL/min per m(2) body surface area; P < 0.001), whereas patients with compensated liver cirrhosis or chronic hepatitis had levels of nitric oxide output similar to those found in controls. Cardiac index was greater in patients with liver cirrhosis (Child C patients, 4.3 +/- 0.3 L/min per m(2) body surface area) than in controls (2.9 +/- 0.2 L/min per m(2) body surface area; P < 0.001). Cardiac index correlated with nitric oxide levels (r = 0.621; P < 0.001). Conclusions: Increased nitric oxide output in exhaled air is associated with systemic circulatory disturbances in patients with liver cirrhosis.

引用

页码：110 / 113

页数：4

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