APOLIPOPROTEIN-E GENOTYPES AND AGE-OF-ONSET IN EARLY-ONSET FAMILIAL ALZHEIMERS-DISEASE

被引：62

作者：

LEVYLAHAD, E

LAHAD, A

WIJSMAN, EM

BIRD, TD

SCHELLENBERG, GD

机构：

[1] VET AFFAIRS MED CTR,CTR GERIATR RES EDUC & CLIN,SEATTLE,WA 98108

[2] UNIV WASHINGTON,DIV MED GENET,SEATTLE,WA 98195

[3] UNIV WASHINGTON,DIV GERONTOL & GERIATR MED,SEATTLE,WA

[4] UNIV WASHINGTON,DEPT MED,SEATTLE,WA

[5] UNIV WASHINGTON,DEPT BIOSTAT,SEATTLE,WA 98195

[6] UNIV WASHINGTON,SCH PUBL HLTH,SEATTLE,WA 98195

[7] VET AFFAIRS MED CTR,DEPT NEUROL,SEATTLE,WA 98108

来源：

ANNALS OF NEUROLOGY | 1995年 / 38卷 / 04期

关键词：

D O I：

10.1002/ana.410380420

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. The epsilon 4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early-onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE-independent pathways.

引用

页码：678 / 680

页数：3

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