APPRAISAL OF RABIES VACCINE POTENCY BY DETERMINATION OF INVITRO, SPECIFIC INTERLEUKIN-2 PRODUCTION

被引:18
作者
JOFFRET, ML
ZANETTI, C
MORGEAUX, S
LECLERC, C
SUREAU, P
PERRIN, P
机构
[1] INST PASTEUR, UNITE RAGE, BIOL REGULAT IMMUNITAIRES, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
[2] INST PASTEUR, BIOL REGULAT IMMUNITAIRES LAB, F-75724 PARIS 15, FRANCE
[3] INST PASTEUR, CTR COLLABORATEUR OMS, UNITE RAGE, F-75724 PARIS 15, FRANCE
关键词
D O I
10.1016/1045-1056(91)90009-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4+CD8- lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from different rabies and rabies-related strains. IL-2 production was specilic, reproducible and correlated with the vaccine protective activity as determined by the pre-exposure NIH test. Our results suggest that measurement of IL-2 production could be used for the appraisal of rabies vaccine potency. © 1991.
引用
收藏
页码:113 / 123
页数:11
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