A GENERAL PARAMETRIC APPROACH TO THE METAANALYSIS OF RANDOMIZED CLINICAL-TRIALS

被引：635

作者：

WHITEHEAD, A

WHITEHEAD, J

机构：

[1] Department of Applied Statistics, University of Reading, Reading, RG6 2AN, Whiteknights

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 11期

关键词：

D O I：

10.1002/sim.4780101105

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meta-analysis provides a systematic and quantitative approach to the summary of results from randomized studies. Whilst many authors have published actual meta-analyses concerning specific therapeutic questions, less has been published about comprehensive methodology. This article presents a general parametric approach, which utilizes efficient score statistics and Fisher's information, and relates this to different methods suggested by previous authors. Normally distributed, binary, ordinal and survival data are considered. Both the fixed effects and random effects model for treatments are described.

引用

页码：1665 / 1677

页数：13

共 20 条

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