A TOTAL SYNTHESIS OF (-)-RUSPOLINONE

被引：19

作者：

JONES, K

WOO, KC

机构：

[1] Department of Chemistry, King's College London, Strand, London

来源：

TETRAHEDRON | 1991年 / 47卷 / 34期

关键词：

RUSPOLINONE; PROLINE; PYRROLIDINE ALKALOIDS; ASYMMETRIC SYNTHESIS;

D O I：

10.1016/S0040-4020(01)96170-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the pyrrolidine alkaloid (-)-ruspolinone (1) from (2S)-proline in 7 steps and 26% overall yield is presented which assigns the (2S) configuration to (-)-(1). The compound obtained by this route has [alpha]D-29.73-degrees compared to a value of zero for the material isolated from the plant suggesting racemisation had occurred during isolation.

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页码：7179 / 7184

页数：6

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