HETEROGENEITY OF METABOLIC RESPONSE TO MUSCULAR EXERCISE IN HUMANS - NEW CRITERIA OF INVARIANCE DEFINED BY INVIVO P-31 NMR-SPECTROSCOPY

被引：100

作者：

BENDAHAN, D ^{[1
]}

CONFORTGOUNY, S ^{[1
]}

KOZAKREISS, G ^{[1
]}

COZZONE, PJ ^{[1
]}

机构：

[1] FAC MED MARSEILLE,CTR RESONANCE MAGNET BIOL & MED,27 BD JEAN MOULIN,F-13005 MARSEILLE,FRANCE

来源：

FEBS LETTERS | 1990年 / 272卷 / 1-2期

关键词：

Human muscle; Intracellular acidosis; NMR spectroscopy; in vivo; Phosphorylated metabolite;

D O I：

10.1016/0014-5793(90)80472-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

31P NMR spectroscopy at 4.7 T has been used in vivo to follow metabolic changes associated with exercise and subsequent recovery in the forearm flexor digitorum superficial muscle of 14 healthy volunteers. The muscle content in phosphomonoesters at rest provides an index of glycogenolytic activity. Quantitative linear correlations have been shown to link end-of-exercise acidosis to recovery kinetics of phosphocreatine and phosphocreatine/organic phosphate ratio. These linear relationships constitute new metabolic invariants to be used in the study of myopathies and muscle adaptation to exercise. © 1990.

引用

页码：155 / 158

页数：4

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