GLYCEROPHOSPHOETHANOLAMINE CONCENTRATION IS ELEVATED IN BRAIN OF PATIENTS WITH DOMINANTLY INHERITED OLIVOPONTOCEREBELLAR ATROPHY

被引：14

作者：

KISH, SJ

ROBITAILLE, Y

BALL, M

GILBERT, J

DECK, JHN

CHANG, LJ

SCHUT, L

机构：

[1] BAYCREST CTR GERIATR CARE,ROTMAN RES INST,TORONTO,ONTARIO,CANADA

[2] MONTREAL NEUROL HOSP & INST,MONTREAL H3A 2B4,QUEBEC,CANADA

[3] OREGON HLTH SCI UNIV,PORTLAND,OR 97201

[4] VICTORIA HOSP,LONDON N6A 4G5,ONTARIO,CANADA

[5] TORONTO GEN HOSP,TORONTO M5G 1L7,ONTARIO,CANADA

[6] UNIV MINNESOTA,MINNEAPOLIS,MN 55455

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 02期

关键词：

DOMINANTLY INHERITED OLIVOPONTOCEREBELLAR ATROPHY; GLYCEROPHOSPHOETHANOLAMINE; PHOSPHOLIPASE-A2; BRAIN; MEMBRANE; PHOSPHOLIPID;

D O I：

10.1016/0304-3940(90)90040-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured the concentration of glycerophosphoethanolamine (GPEA), a membrane breakdown product, in autopsied brain of 10 patients with dominantly inherited olivopontocerebellar atrophy (OPCA), a cerebellar ataxia disorder. As compared with the controls, mean GPEA levels were significantly elevated by 37-69% in 11 of the 15 brain areas examined, including extracerebellar brain regions in which no neuronal cell loss could be detected by semiquantitative estimation. Our data suggest the pos sibility of altered membrane phospholipid metabolism in OPCA which could be a contributing factor in the neuronal cell death.

引用

页码：209 / 211

页数：3

共 17 条

[1]

BLUSZTAJN JK, IN PRESS BRAIN RES

[2]

CURRIER R, 1984, ITAL J NEUROL SCI S, V4, P55

[3] SPINOCEREBELLAR ATAXIA - STUDY OF A LARGE KINDRED .1. GENERAL INFORMATION AND GENETICS [J].