DIETARY FATTY-ACID THRESHOLDS AND CHOLESTEROLEMIA

被引:193
作者
HAYES, KC
KHOSLA, P
机构
[1] Foster Biomedical Research Lab., Brandeis University, Waltham
关键词
FATTY ACIDS; PLASMA CHOLESTEROL; MYRISTIC ACID; LINOLEIC ACID; CEBUS MONKEYS;
D O I
10.1096/fasebj.6.8.1592210
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Results obtained with cebus monkeys indicate that dietary myristic (14:0) and palmitic (16:0) acids exert disparate effects on cholesterol metabolism, whereas the ability of linoleic acid (18:2) to decrease total plasma cholesterol displays an upper limit or threshold. Reanalysis of published data suggests a similar situation pertains in humans. In agreement with an earlier human study, 14:0 appears to be the principal saturated fatty acid that raises plasma cholesterol whereas 18:2 lowers it. Oleic acid (18:1) appears neutral. The effect of 16:0 may vary. In normocholesterolemic subjects consuming diets containing less-than-or-equal-to 300 mg/day of cholesterol, 16:0 appears to be without effect on plasma cholesterol. However, in hypercholesterolemic subjects (> 225 mg/dl) and especially those consuming diets providing cholesterol intakes of greater-than-or-equal-to 400 mg/day, dietary 16:0 may expand the plasma cholesterol pool.
引用
收藏
页码:2600 / 2607
页数:8
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