SMOOTH-MUSCLE ALPHA-ACTIN PROMOTER ACTIVITY IS INDUCED BY SERUM STIMULATION OF FIBROBLAST CELLS

被引：30

作者：

KIM, JH

BUSHEL, PR

KUMAR, CC

机构：

[1] Department of Tumor Biology, Schering-Plough Research Institute, Kenilworth

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transient transfection analysis of a plasmid containing human α-actin promoter linked to bacterial chloramphenicol acetyl transferase (CAT) reporter gene, in Rat-2 fibroblast cells, indicates that smooth muscle (sm) α-actin promoter activity is induced by serum. The CArG [CC(A/T)6GG] box sequences within the α-actin promoter mediate the serum induction. This induction can be blocked by overexpression of Fos, suggesting that it follows the same regulatory pathway as c-fos. © 1993 Academic Press.

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页码：1115 / 1121

页数：7

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