GLYCOSAMINOGLYCANS IN THYROID-ASSOCIATED OPHTHALMOPATHY

被引：31

作者：

KAHALY, G

STOVER, C

OTTO, E

BEYER, J

SCHULER, M

机构：

[1] III Department of Medicine and Endocrinology, Johannes Gutenberg University Hospital, Mainz

来源：

AUTOIMMUNITY | 1992年 / 13卷 / 01期

关键词：

GLYCOSAMINOGLYCANS; THYROID-ASSOCIATED OPHTHALMOPATHY; RETROBULBAR FIBROBLASTS;

D O I：

10.3109/08916939209014639

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies. In order to gain further insight into possible immunopathogenic mechanisms, the influence of humoral immunity on retrobulbar fibroblasts (RF) as GAG producing cells as well as on GAGs themselves was investigated. The effect of lymphocytes on hyaluronic acid (HA) synthesis of RF as well as in tum the influence of RF on lymphocytes were evaluated. In search of methods which would facilitate management of patients with TAO and allow assessment of disease activity, GAGs were determined in both urine and plasma. Immunoglobulin G (IgG) of patients with TAO were found to markedly stimulate the H-3-GAG secretion of RF. Patients with TAO exhibited significantly greater antibody values directed against HA than controls. Preliminary results concerning the influence of lymphocytes on RF indicate a tendency for patients' lymphocytes to increase the synthesis of HA. Furthermore, these lymphocytes in tum were stimulated more by irradiated autologous RF than by irradiated heterologous RF. Urine and plasma GAG determination proved to be suitable for the routine assessment of disease activity and outcome of therapy. In conclusion, GAGs seem to play an important role in the pathogenesis of the disease and their measurement may provide aid to the endocrinological evaluation of patients with TAO.

引用

页码：81 / 88

页数：8

共 59 条

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