CYTOGENETIC AND LOSS OF HETEROZYGOSITY STUDIES IN EPENDYMOMAS, PILOCYTIC ASTROCYTOMAS, AND OLIGODENDROGLIOMAS

被引:159
作者
RANSOM, DT
RITLAND, SR
KIMMEL, DW
MOERTEL, CA
DAHL, RJ
SCHEITHAUER, BW
KELLY, PJ
JENKINS, RB
机构
[1] MAYO CLIN & MAYO FDN,LAB GENET SECT,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,DEPT NEUROL,ROCHESTER,MN 55905
[3] MAYO CLIN & MAYO FDN,SURG PATHOL SECT,ROCHESTER,MN 55905
[4] MAYO CLIN & MAYO FDN,DEPT NEUROSURG,ROCHESTER,MN 55905
关键词
D O I
10.1002/gcc.2870050411
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cytogenetic and/or loss of heterozygosity studies were performed on 13 ependymomas, 11 pilocytic astrocytomas, and 18 oligodendrogliomas. Loss of chromosome 22 was the most frequent genetic abnormality among the ependymomas. We found no consistent genetic abnormality in pilocytic astrocytomas. The most common genetic abnormality in oligodendrogliomas was loss of a portion of chromosome 19. Each informative oligodendroglioma had loss of alleles mapped to the long arm (q) of chromosome 19. One oligodendroglioma had an apparent homozygous deletion of the D19S8 locus. Our results, when combined with those in the literature, indicate that chromosomes 9, 11, and 22 may harbor genes important for the pathogenesis of ependymomas and that 19q probably harbors a gene important for the pathogenesis of oligodendrogliomas.
引用
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页码:348 / 356
页数:9
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