CLEAVAGE OF PEPTIDES BOUND TO MERRIFIELD RESINS BY POTASSIUM CARBONATE IN THE PRESENCE OF A PHASE-TRANSFER REAGENT

被引：13

作者：

ANWER, MK ^{[1
]}

SPATOLA, AF ^{[1
]}

机构：

[1] UNIV LOUISVILLE,DEPT CHEM,LOUISVILLE,KY 40292

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79829-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetra-n-butylammonium carbonate (TBAC) [prepared in situ from potassium carbonate and tetra-n-butylammonium hydrogen sulphate (TBAHS)] has been utilized to release peptides in an N(alpha)-protected form from their Merrifield resin supports. The partially protected peptides were obtained in good yields (70 to 100%) and purity (85 to 90% by reversed phase high performance liquid chromatography (RP-HPLC)).

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页码：3121 / 3124

页数：4

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