GLUTAMYL-TRANSFER RNA - A PRECURSOR OF HEME AND CHLOROPHYLL BIOSYNTHESIS

被引：164

作者：

JAHN, D

VERKAMP, E

SOLL, D

机构：

[1] Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0968-0004(92)90380-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In green plants, archaebacteria and many eubacteria, the porphyrin ring that is common to both chlorophyll and heme is synthesized from 5-aminolevulinic acid (ALA) via an interesting pathway. This two-step process involves the unusual enzymes glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase. Interest in this pathway has increased since it was discovered that a tRNA cofactor was required for the formation of ALA. This tRNA(Glu) is common to the biosyntheses of both porphyrins and proteins,

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页码：215 / 218

页数：4

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