L-DOPA STIMULATES C-FOS EXPRESSION IN DOPAMINE DENERVATED STRIATUM BY COMBINED ACTIVATION OF D-1 AND D-2 RECEPTORS

被引：48

作者：

MORELLI, M

COZZOLINO, A

PINNA, A

FENU, S

CARTA, A

DICHIARA, G

机构：

[1] Department of Toxicology, University of Cagliari, Cagliari

来源：

BRAIN RESEARCH | 1993年 / 623卷 / 02期

关键词：

DOPAMINE; L-DOPA; C-FOS; STRIATUM; DOPAMINE-D(1) RECEPTOR; DOPAMINE-D(2) RECEPTOR;

D O I：

10.1016/0006-8993(93)91449-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Administration Of L-dopa to unilaterally 6-hydroxydopamine-lesioned rats, activates the early gene c-fos in the lesioned caudate-putamen. D-1 receptor blockade by SCH 23390, prevented L-dopa-induced Fos-like immunoreactivity in the whole caudate-putamen, while D-2 receptor blockade by raclopride reduced Fos-like immunoreactivity only in the dorso-lateral portion. The results suggest that L-dopa induces c-fos primarily through an activation of D-1 receptors, while D-2 receptor stimulation plays a facilitatory influence on D-1-mediated c-fos expression.

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收藏

页码：334 / 336

页数：3

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