PREPARATION OF L-(PHOSPHONODIFLUOROMETHYL)PHENYLALANINE DERIVATIVES AS NONHYDROLYZABLE MIMETICS OF O-PHOSPHOTYROSINE

被引：59

作者：

WROBEL, J

DIETRICH, A

机构：

[1] Wyeth-Ayerst Research, Inc., Princeton, NJ 08543-8000

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73631-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-t-BOC-L-(Phosphonodifluoromethyl)phenylalanine benzyl ester (1) was in 5 steps from N-t-BOC-L-tyrosine benzyl ester O-triflate (4). Compound 1 was further converted to derivatives 2 and 3 which are potentially suitable for peptide synthesis. Analogs 1 - 3 are non-hydrolyzable mimetics of O-phosphotyrosine.

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页码：3543 / 3546

页数：4

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