COGNITIVE AND MOLECULAR ASPECTS OF FRAGILE-X

被引：14

作者：

HINTON, VJ

HALPERIN, JM

DOBKIN, CS

DING, XH

BROWN, WT

MIEZEJESKI, CM

机构：

[1] CUNY,QUEENS COLL,NEW YORK,NY 10021

[2] CUNY,GRAD SCH,NEW YORK,NY 10021

[3] CSI IBR CTR DEV NEUROSCI,NEW YORK,NY

[4] MT SINAI SCH MED,NEW YORK,NY

[5] NEW YORK STATE INST BASIC RES DEV DISABIL,STATEN ISL,NY

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 1995年 / 17卷 / 04期

关键词：

D O I：

10.1080/01688639508405142

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The relationships among pal ental origin of the fragile X gene, gene structure, and specific cognitive deficits were evaluated in nonretarded adult female fragile X carriers to determine whether: (1) origin influences gene structure and cognitive function, (2) mild cognitive impairments are associated with altered gene structure, and (3) specific cognitive domains are affected. Results indicated that 56% of women with maternally inherited, but none with paternally inherited, fragile X showed large genomic structural alterations and selective deficits on measures of visual attention. Thus, molecular status of the fragile X gene appears to be linked to parental origin and may selectively affect specific cognitive skills.

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收藏

页码：518 / 528

页数：11

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