EPIRUBICIN, CISPLATIN AND INFUSIONAL 5-FLUOROURACIL (5-FU) (ECF) IN HEPATOBILIARY TUMORS

被引：122

作者：

ELLIS, PA

NORMAN, A

HILL, A

OBRIEN, MER

NICHOLSON, M

HICKISH, T

CUNNINGHAM, D

机构：

[1] INST CANC RES,MED SECT,CRC,SUTTON SM2 5PT,SURREY,ENGLAND

[2] INST CANC RES,GI UNIT,SUTTON SM2 5PT,SURREY,ENGLAND

[3] ROYAL MARSDEN HOSP,SUTTON SM2 5PT,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 10期

关键词：

EPIRUBICIN; CISPLATIN AND INFUSIONAL 5-FLUOROURACIL; (5-FU) (ECF) IN HEPATOBILIARY TUMORS;

D O I：

10.1016/0959-8049(95)00323-B

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatobiliary tumours are rare, often present late and have a poor prognosis, with no current effective systemic therapy available. This study aimed to evaluate the activity and toxicity of epirubicin, cisplatin and continuous infusional 5-fluorouracil (5-FU) (ECF) in patients with these tumours. From March 1991 to November 1993, 25 patients with advanced biliary tumours and 7 with hepatoma were treated with epirubicin 50 mg/m(2) and cisplatin 60 mg/m(2) intravenously (i.v.) day 1, each given every 21 days and 5-FU 200 mg/m(2)/day given as a continuous 24 h i.v. infusion throughout the treatment course. 8 of the 20 (40%) evaluable patients with biliary tumours responded. Median duration of response was 10 months. 2 of the 7 (29%) patients with hepatoma responded. The regimen was well tolerated with minimal haematological and non-haematological toxicity. This novel regimen is active in advanced hepatobiliary tumours.

引用

页码：1594 / 1598

页数：5

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