GENERATION OF SOFT X-RAYS BY USING THE FREE-ELECTRON LASER AS A PROPOSED MEANS OF DIAGNOSING AND TREATING BREAST-CANCER

被引:4
作者
CARROLL, FE
机构
[1] Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee
关键词
COMPTON BACKSCATTER; MONOCHROMATIC X-RAYS; BREAST LESIONS;
D O I
10.1002/lsm.1900110115
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The diagnosis and treatment of breast lesions may be markedly enhanced by the use of a unique new source of near-monochromatic x-rays. Concentric beams of near-monochromatic x-ray photons may be generated by collision of the free electron laser (FEL) electron beam with the optical beam in an interaction zone that delivers the x-rays to a shirtsleeve environment. The absence of Compton scatter and the photoelectric interaction within tissues improves conspicuity of lesions by two to six times. Increased attenuation of x-rays in malignant vs. normal tissues makes tumors more obvious. K-edge subtraction allows chemical analysis of tumors in vivo-all at radiation doses that are one-tenth to one-fiftieth that delivered by the lowest-dose mammographic x-ray technique available. This allows for an increased sensitivity and specificity and permits prediction of histology, negating necessity for biopsies. Selective bond-breaking at depth in tissues as well as x-ray-activated photodynamic therapy are also being explored.
引用
收藏
页码:72 / 78
页数:7
相关论文
共 4 条
[1]  
BRAU C, 1990, FREE ELECTRON LASERS
[2]  
CARROLL FE, 1989, DIAGN IMAGING, V11, P291
[3]  
CARROLL FE, 1990, INVEST RADIOL, V5, P465
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