INVITRO INDUCTION OF SPECIFIC T-CELLS ABLE TO HELP IN THE GENERATION OF DELAYED-TYPE HYPERSENSITIVITY BY THYMUS-DEPENDENT AND TYPE-II THYMUS-INDEPENDENT ANTIGENS

被引：5

作者：

BRETSCHER, PA ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT MED, EDMONTON T6G 2H7, ALBERTA, CANADA

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1984年 / 20卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1984.tb01034.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An in vitro system is described which supports the primary induction of T cells able to help in the induction of delayed-type hypersensitivity. This system is used to demonstrate that hapten-Ficoll conjugates induce potent hapten-specific T cells with this function. These type-II ''thymus-independent'' antigens are thus able to induce specific regulatory T cells. These helper T cells are similar to those induced by classical thymus-dependent antigens in that they are specific for antigen rather than idiotype and act by a linked mechanism.

引用

页码：519 / 525

页数：7

共 14 条

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