EFFECT OF THE EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA-2 IN PRIMARY HUMAN GLIOBLASTOMAS ON IMMUNOSUPPRESSION AND LOSS OF IMMUNE SURVEILLANCE

被引：100

作者：

MAXWELL, M

GALANOPOULOS, T

NEVILLEGOLDEN, J

ANTONIADES, HN

机构：

[1] MASSACHUSETTS GEN HOSP,CTR BLOOD RES,BOSTON,MA 02114

[2] MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114

[3] HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115

[4] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

[5] HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,BOSTON,MA 02115

[6] RADCLIFFE INFIRM,DEPT NEUROPATHOL,OXFORD OX2 6HE,ENGLAND

[7] UNIV OXFORD,DEPT CLIN NEUROL,OXFORD,ENGLAND

来源：

JOURNAL OF NEUROSURGERY | 1992年 / 76卷 / 05期

关键词：

GLIOBLASTOMA; TRANSFORMING GROWTH FACTOR-BETA; ONCOGENE; INSITU HYBRIDIZATION;

D O I：

10.3171/jns.1992.76.5.0799

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastomas are malignant brain tumors that are attended by an immunosuppressed state. The authors have studied the expression of transforming growth factor-beta-2, which is known to have potent immunosuppressive and angiogenic properties. Transforming growth factor-beta-2 messenger ribonucleic acid and its protein product are both found to be greatly overexpressed in these tumors and are absent from normal brain tissue. The overexpression of this growth factor may contribute to the escape of neoplastic astrocytes from immune surveillance and, furthermore, to the immunosuppressed state that is characteristic of many of these patients.

引用

页码：799 / 804

页数：6

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