NONOPIOID ANTITUSSIVES INHIBIT ENDOGENOUS GLUTAMATE RELEASE FROM RABBIT HIPPOCAMPAL SLICES

被引：36

作者：

ANNELS, SJ ^{[1
]}

ELLIS, Y ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT PHARMACOL & THERAPEUT,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES

来源：

BRAIN RESEARCH | 1991年 / 564卷 / 02期

关键词：

NONOPIOID ANTITUSSIVE; GLUTAMATE RELEASE; HIPPOCAMPAL SLICE;

D O I：

10.1016/0006-8993(91)91474-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The non-opioid antitussive drugs, dextromethorphan, caramiphen and carbetapentane, are also anticonvulsant. The effects of these antitussives on potassium-stimulated release of endogenous amino acids from rabbit hippocampal slices was tested. All 3 drugs significantly reduced the release of glutamate, with carbetapentane being the most potent (IC50 approximately 40-mu-M). We suggest that the anticonvulsant action may be due to their ability to decrease glutamate release.

引用

页码：341 / 343

页数：3

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