SERUM DEHYDROEPIANDROSTERONE SULFATE IN ALZHEIMERS-DISEASE AND IN MULTIINFARCT DEMENTIA

被引：116

作者：

NASMAN, B

OLSSON, T

BACKSTROM, T

ERIKSSON, S

GRANKVIST, K

VIITANEN, M

BUCHT, G

机构：

[1] UMEA UNIV HOSP, DEPT INTERNAL MED, S-90185 UMEA, SWEDEN

[2] UMEA UNIV HOSP, DEPT OBSTET & GYNECOL, S-90185 UMEA, SWEDEN

[3] UMEA UNIV HOSP, DEPT CLIN CHEM, S-90185 UMEA, SWEDEN

[4] KAROLINSKA INST, HUDDINGE HOSP, DEPT GERIATR MED, S-10401 STOCKHOLM 60, SWEDEN

来源：

BIOLOGICAL PSYCHIATRY | 1991年 / 30卷 / 07期

关键词：

D O I：

10.1016/0006-3223(91)90013-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.

引用

页码：684 / 690

页数：7

共 30 条

[1] STUDIES OF CONJUGATED 17-KETOSTEROIDS IN A CASE OF ADRENAL TUMOR [J].