EVIDENCE FOR 2 CA-2+-MOBILIZING PURINOCEPTORS ON RAT HEPATOCYTES

被引：86

作者：

DIXON, CJ

WOODS, NM

CUTHBERTSON, KSR

COBBOLD, PH

机构：

[1] Department of Human Anatomy, University of Liverpool, Liverpool L69 3BX

来源：

BIOCHEMICAL JOURNAL | 1990年 / 269卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bj2690499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Aequorin measurements of cytosolic free Ca2+ in single rat hepatocytes show that ADP and ATP, thought to act through the same P(2Y) purinoceptor, elicited very different responses in the majority of cells tested. ADP invariably induced transients of short duration (approx. 9 s), whereas ATP induced either similar transients or transients with a much longer duration (approx. 49 s). We explain this variability in terms of two separate purinoceptors on rat hepatocytes, one of which responds to either ATP or ADP to generate free-Ca2+ transients of short duration, and the other responds to ATP only, with transients of longer duration.

引用

页码：499 / 502

页数：4

共 22 条

[1]

A NOVEL RECEPTOR-OPERATED CA-2+-PERMEABLE CHANNEL ACTIVATED BY ATP IN SMOOTH-MUSCLE [J].