MEDIATION OF NITROUS-OXIDE ANALGESIA IN MICE BY SPINAL AND SUPRASPINAL KAPPA-OPIOID RECEPTORS

被引：33

作者：

QUOCK, RM

BEST, JA

CHEN, DC

VAUGHN, LK

PORTOGHESE, PS

TAKEMORI, AE

机构：

[1] UNIV MINNESOTA,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,COLL PHARM,DEPT MED CHEM,MINNEAPOLIS,MN 55455

[3] MARQUETTE UNIV,SCH DENT,DEPT ARTIFICIAL INTELLIGENCE,MILWAUKEE,WI 53233

[4] MARQUETTE UNIV,SCH DENT,DEPT PEDIAT DENT,MILWAUKEE,WI 53233

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 01期

关键词：

Analgesia; Narcotic antagonists; Nitrous oxide; Opioid receptors;

D O I：

10.1016/0014-2999(90)90158-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors. © 1990.

引用

页码：97 / 100

页数：4

共 11 条

[1] PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE [J].