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THE EFFECT OF DI(ETHYLHEXYL)PHTHALATE ON FATTY-ACID OXIDATION AND CARNITINE PALMITOYLTRANSFERASE IN VARIOUS RAT-TISSUES

被引：28
作者：
REUBSAET, FAG
VEERKAMP, JH
DIRVEN, HAAM
BRUCKWILDER, MLP
HASHIMOTO, T
TRIJBELS, JMF
MONNENS, LAH
机构：
[1] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,POB 9101,6500 HB NIJMEGEN,NETHERLANDS
[2] CATHOLIC UNIV NIJMEGEN,DEPT PEDIAT,6500 HB NIJMEGEN,NETHERLANDS
[3] CATHOLIC UNIV NIJMEGEN,DEPT TOXICOL,6500 HB NIJMEGEN,NETHERLANDS
[4] SHINSHU UNIV,DEPT BIOCHEM,MATSUMOTO,NAGANO 390,JAPAN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1047卷 / 03期
关键词：
FATTY ACID OXIDATION; DI(ETHYLHEXYL)PHTHALATE; CARNITINE PALMITOYLTRANSFERASE; CYTOCHROME-C OXIDASE; (RAT PEROXISOME);
D O I：
10.1016/0005-2760(90)90525-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Male rats were fed a diet with or without 2% di(2-ethylhexyl)phthalate (DEHP) for 12 days. Total and peroxisomal oxidation rates of palmitic and arachidonic acid were increased in homogenates of liver and kidney after DEHP administration. The relative peroxisomal contribution to the total oxidation was only higher in liver. The activities of acyl-CoA oxidase and carnitine palmitoyltransferase were also higher in both tissues. Immunoblots showed that the increase of fatty acid oxidation was associated with a higher concentration of enzymes of peroxisomal and mitochondrial beta-oxidation. DEHP did not change total and peroxisomal fatty acid oxidation and activity of carnitine palmitoyltransferase of homogenates of heart and skeletal muscle. The cause for the tissue-specific response is discussed.
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收藏
页码：264 / 270
页数：7
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