DNA CLONING AND ORGANIZATION OF THE STAPHYLOCOCCUS-AUREUS GYRA AND GYRB GENES - CLOSE HOMOLOGY AMONG GYRASE PROTEINS AND IMPLICATIONS FOR 4-QUINOLONE ACTION AND RESISTANCE

被引：61

作者：

HOPEWELL, R ^{[1
]}

ORAM, M ^{[1
]}

BRIESEWITZ, R ^{[1
]}

FISHER, LM ^{[1
]}

机构：

[1] UNIV LONDON ST GEORGES HOSP,SCH MED,DIV BIOCHEM,DEPT CELLULAR & MOLEC SCI,MOLEC GENET GRP,LONDON SW17 0RE,ENGLAND

来源：

JOURNAL OF BACTERIOLOGY | 1990年 / 172卷 / 06期

关键词：

D O I：

10.1128/jb.172.6.3481-3484.1990

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus gyrA and gyrB genes, which encode the DNA gyrase A and B proteins, have been isolated and found to map contiguously. DNA sequence analysis revealed close homology between the S. aureus gyrase subunits and their counterparts in Bacillus subtilis and Escherichia coli, including several conserved amino acid residues whose substitution in E. coli confers resistance to 4-quinolones. These results are discussed in regard to quinolone resistance mechanisms in S. aureus.

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页码：3481 / 3484

页数：4

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