STRUCTURAL BASIS OF VOLTAGE-GATED K+ CHANNEL PHARMACOLOGY

被引：81

作者：

PONGS, O

机构：

[1] Zentrum für Molekulare Neurobiologie, Universität Hamburg, D-2000 Hamburg 20, Martinistrasse 52

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 09期

关键词：

D O I：

10.1016/0165-6147(92)90109-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Major advances have been made in understanding the domains and amino acid sidechains important for the function of voltage-gated K+ channels, by combining recombinant DNA techniques with pharmacological and electrophysiological approaches. As explained in this review by Olaf Pongs, the results of these experiments have enabled description of a detailed model of the K+ channel pore structure and provide an exciting picture of how open-channel blockers occlude the pore of K+ channels. Since the pore is a highly conserved structure among voltage-gated K+ channels, there are only limited possibilities for open K+ channel blockers to distinguish between the many distinct voltage-gated K+ channels, which have diverse kinetic and conductance properties.

引用

页码：359 / 365

页数：7

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