PREPARATION AND RADIOLABELING OF CP-96,345, THE 1ST NONPEPTIDE SUBSTANCE-P ANTAGONIST

被引：24

作者：

LOWE, JA

DROZDA, SE

SNIDER, RM

LONGO, KP

BORDNER, J

机构：

[1] Central Research Division, Pfizer, Groton, CT 06340, Inc. Eastern Point Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)80246-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of CP-96,345, a potent, non-peptide Substance P antagonist, in both enantiomerically pure and radiolabelled forms is described. In addition, the absolute configuration of CP-96,345 was determined to be 2S,3S.

引用

页码：129 / 132

页数：4

共 12 条

[1] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT
BORCH, RF
BERNSTEIN, MD
DURST, HD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) : 2897 - +
[2] AMINO-ACID SEQUENCE OF SUBSTANCE P
CHANG, MM
LEEMAN, SE
NIALL, HD
[J]. NATURE-NEW BIOLOGY, 1971, 232 (29): : 86 - +
[3] SIGNIFICANCE TESTS ON CRYSTALLOGRAPHIC R FACTOR
HAMILTON, WC
[J]. ACTA CRYSTALLOGRAPHICA, 1965, 18 : 502 - &
[4] DISPERSION CORRECTIONS + CRYSTAL STRUCTURE REFINEMENTS
IBERS, JA
HAMILTON, WC
[J]. ACTA CRYSTALLOGRAPHICA, 1964, 17 (06): : 781 - &
[5] MCLEAN S, IN PRESS SCIENCE
[6] BINDING OF [SUBSTANCE-P-H-3 TO PUTATIVE SUBSTANCE-P RECEPTORS IN RAT-BRAIN MEMBRANES
PERRONE, MH
DIEHL, RE
HAUBRICH, DR
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 95 (1-2) : 131 - 133
[7] REGOLI D, 1987, TRENDS CLUSTER HEADA, P85
[8] SHELDRICK GM, 1981, SHELXTL USER MANUAL
[9] SNIDER RM, IN PRESS SCIENCE
[10] An unidentified depressor substance in certain tissue extracts.
von Euler, US
Gaddum, JH
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1931, 72 (01): : 74 - 87

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