CROSS-CULTURAL ASSOCIATION BETWEEN DIETARY ANIMAL PROTEIN AND HIP FRACTURE - A HYPOTHESIS

被引:189
作者
ABELOW, BJ
HOLFORD, TR
INSOGNA, KL
机构
[1] YALE UNIV, SCH MED, DEPT MED, ENDOCRINOL SECT, 333 CEDAR ST, NEW HAVEN, CT 06510 USA
[2] YALE UNIV, SCH MED, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06510 USA
关键词
OSTEOPOROSIS; HIP FRACTURE; ACID-BASE EQUILIBRIUM; VEGETARIANISM; DIETARY PROTEINS; EPIDEMIOLOGY;
D O I
10.1007/BF00297291
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Age-adjusted female hip fracture incidence has been noted to be higher in industrialized countries than in nonindustrialized countries. A possible explanation that has received little attention is that elevated metabolic acid production associated with a high animal protein diet might lead to chronic bone buffering and bone dissolution. In an attempt to examine this hypothesis, cross-cultural variations in animal protein consumption and hip fracture incidence were examined. When female fracture rates derived from 34 published studies in 16 countries were regressed against estimates of dietary animal protein, a strong, positive association was found. This association could not plausibly be explained by either dietary calcium or total caloric intake. Recent studies suggest that the animal protein-hip fracture association could have a biologically tenable basis. We conclude that further study of the metabolic acid-osteoporosis hypothesis is warranted.
引用
收藏
页码:14 / 18
页数:5
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