CYCLOSPORINE-A SUPPRESSION OF UNCOUPLING IN LIVER-MITOCHONDRIA OF GROUND-SQUIRREL DURING AROUSAL FROM HIBERNATION

被引：21

作者：

BRUSTOVETSKY, NN

EGOROVA, MV

GNUTOV, DY

MOKHOVA, EN

SKULACHEV, VP

机构：

[1] MOSCOW MV LOMONOSOV STATE UNIV,AN BELOZERSKY INST PHYSICOCHEM BIOL,MOSCOW 119899,RUSSIA

[2] RUSSIAN ACAD SCI,INST THEORET EXPTL BIOPHYS,PUSHCHINO 142292,RUSSIA

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

THERMOREGULATORY UNCOUPLING; CYCLOSPORINE-A; FATTY ACID; HIBERNATION;

D O I：

10.1016/0014-5793(93)81170-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Energy coupling parameters were studied in liver mitochondria of ground squirrel during arousal from hibernation. It was found that such mitochondria become uncoupled during incubation with phosphate in a salt medium. The uncoupling was revealed by respiration rate increase and membrane potential decrease in the presence of oligomycin. Both effects were reversed by addition of cyclosporin A. Under the same in vitro conditions, mitochondria from aroused (active) animals showed no uncoupling but could be uncoupled by addition of palmitate in the cyclosporin A-sensitive fashion. It is proposed that formation of cyclosporin A-sensitive pores can be involved in urgent heat production in arousing hibernators.

引用

页码：233 / 236

页数：4

共 18 条

[1] THE ATP-ADP-ANTIPORTER IS INVOLVED IN THE UNCOUPLING EFFECT OF FATTY-ACIDS ON MITOCHONDRIA [J].