IMPROVED-TUMOR TARGETING WITH RECOMBINANT ANTIBODY-MACROCYCLE CONJUGATES

被引：36

作者：

NORMAN, TJ

PARKER, D

ROYLE, L

HARRISON, A

ANTONIW, P

KING, DJ

机构：

[1] UNIV DURHAM,DEPT CHEM,DURHAM DH1 3LE,ENGLAND

[2] CELLTECH THERAPEUT LTD,SLOUGH SL1 4EN,BERKS,ENGLAND

[3] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,OXON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 18期

关键词：

D O I：

10.1039/c39950001877

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Linkage of a macrocyclic complexing:agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Delta-Cys Fab fragment of an engineered human antibody.

引用

页码：1877 / 1878

页数：2

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