Cooperation of Cancer Stem Cell Properties and Epithelial-Mesenchymal Transition in the Establishment of Breast Cancer Metastasis

被引：48

作者：

Hayashida, Tetsu ^{[1
]}

Jinno, Hiromitsu ^{[1
]}

Kitagawa, Yuko ^{[1
]}

Kitajima, Masaki ^{[2
]}

机构：

[1] Keio Univ, Dept Surg, Sch Med, Shinjyuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[2] Int Univ Hlth & Welf, Dept Surg, Minato Ku, Tokyo 1088329, Japan

来源：

JOURNAL OF ONCOLOGY | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/591427

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epithelial-mesenchymal transition (EMT) is a multistep process in which cells acquire molecular alterations such as loss of cell-cell junctions and restructuring of the cytoskeleton. There is an increasing understanding that this process may promote breast cancer progression through promotion of invasive and metastatic tumor growth. Recent observations imply that there may be a cross-talk between EMT and cancer stem cell properties, leading to enhanced tumorigenicity and the capacity to generate heterogeneous tumor cell populations. Here, we review the experimental and clinical evidence for the involvement of EMT in cancer stem cell theory, focusing on the common characteristics of this phenomenon.

引用

页数：7

共 82 条

[1]

Abraham BK, 2005, CLIN CANCER RES, V11, P1154

[2]

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients [J].