CHROMATOGRAPHIC-SEPARATION AND PHOTOELECTROCHEMICAL DETECTION OF SODIUM-NITROPRUSSIDE AND ITS DEGRADATIVE AND METABOLIC PRODUCTS

被引：4

作者：

AYERS, TH

METWALLY, MES

HONIGBERG, IL

机构：

[1] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM,ATHENS,GA 30602

[2] MANSOURA UNIV,FAC PHARM,DEPT ANALYT CHEM,MANSOURA,EGYPT

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 06期

关键词：

degradation ions; ion-pair chromatography; Nitroprusside; photoelectrochemical detector; thiocyanate;

D O I：

10.1016/0731-7085(90)80062-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ion-pair chromatography has been used for the separation of nitroprusside ion and its photochemical hydrolytic and metabolic products. Organic modifier and pH were adjusted for maximum separation of the ions. Methanol was selected as the organic modifier in a pH range 5-8 and tetrabutylammonium perchlorate was used as the ion-pairing reagent. Ions were detected with a photoelectrochemical detector as described by Krull. A modification of this procedure was used to detect nitroprusside ion in spiked serum samples. © 1990.

引用

页码：521 / 526

页数：6

共 17 条

[1] SIMPLE METHOD OF PACKING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY COLUMNS WITH HIGH REPRODUCIBILITY [J].