EFFICACY OF NUCLEOPROTEIN AND HEMAGGLUTININ ANTIGENS EXPRESSED IN FOWLPOX VIRUS AS VACCINE FOR INFLUENZA IN CHICKENS

被引：118

作者：

WEBSTER, RG ^{[1
]}

KAWAOKA, Y ^{[1
]}

TAYLOR, J ^{[1
]}

WEINBERG, R ^{[1
]}

PAOLETTI, E ^{[1
]}

机构：

[1] VIROGENET CORP, TROY, NY 12180 USA

来源：

VACCINE | 1991年 / 9卷 / 05期

关键词：

FOWLPOX VIRUS; CHICKENS; RECOMBINANTS; INFLUENZA;

D O I：

10.1016/0264-410X(91)90055-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fowlpox virus (FPV) recombinants expressing influenza virus H5 haemagglutinin (HA), nucleoprotein (NP) or co-expressing both of these antigens were tested for vaccine efficacy in chickens. Immunization with the recombinant FPV-HA was highly efficacious but provided no cross protection between subtypes. Bursectomy established that immunity against the H5 subtype was antibody-mediated despite the presence of very low levels of antibody in the vaccinated birds. Immunization with the recombinant FPV expressing the cross-reactive NP antigen did not provide protective immunity despite hyperimmunization and provided no benefit above HA expressed alone. The results suggest that the kinetics of viral replication outpaces immunity induced by NP.

引用

页码：303 / 308

页数：6

共 18 条

[1] EFFICACY OF INFLUENZA HEMAGGLUTININ AND NUCLEOPROTEIN AS PROTECTIVE ANTIGENS AGAINST INFLUENZA-VIRUS INFECTION IN MICE [J].