SWITCH PEPTIDES - PH-INDUCED ALPHA-HELIX TO BETA-SHEET TRANSITIONS OF BIS-AMPHIPHILIC OLIGOPEPTIDES

被引：71

作者：

MUTTER, M

GASSMANN, R

BUTTKUS, U

ALTMANN, KH

机构：

[1] Séction de chimie, Université de Lausanne, Lausanne, CH-1005

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 11期

关键词：

D O I：

10.1002/anie.199115141

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interconversion of two secondary structure types (alpha-helix reversible beta-sheet) induced by external conditions such as pH, temperature, concentration, and solvent could be proved in a new class of amphiphilic peptides (switch peptides) in aqueous solution. The pH-dependent conformational changes were studied by CD spectroscopy. Special attention was given to the investigations of four newly synthesized peptides with similar sequences.

引用

页码：1514 / 1516

页数：3

共 43 条

[1]

ALTMANN KH, 1986, INT J PEPT PROT RES, V27, P314

[2] HOW DOES PROTEIN FOLDING GET STARTED [J].

BALDWIN, RL .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (07) :291-294

[3]

BARANY G, 1980, PEPTIDES, V2, P3

[4]

BONORA GM, 1986, INT J PEPT PROT RES, V27, P1

[5]

Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45

[6]

CREIGHTON TE, 1990, BIOCHEM J, V270, P1

[7] INDUCTION OF PEPTIDE CONFORMATION AT APOLAR WATER INTERFACES .1. A STUDY WITH MODEL PEPTIDES OF DEFINED HYDROPHOBIC PERIODICITY [J].

DEGRADO, WF ;

LEAR, JD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (25) :7684-7689

[8] PROTEIN DESIGN, A MINIMALIST APPROACH [J].

DEGRADO, WF ;

WASSERMAN, ZR ;

LEAR, JD .

SCIENCE, 1989, 243 (4891) :622-628

[9]

EBERT G, 1983, INT J BIOL MACROMOL, V5, P109

[10]

EBERT G, 1985, TOP CURR CHEM, V18, P1

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