CARCINOGENIC NON-AMINOAZO DYE 1-PHENYLAZO-2-HYDROXY-NAPHTHALENE (SUDAN-I) IS OXIDIZED BY RAT-LIVER MICROSOMAL CYTOCHROME-P-450 TO METABOLITES BINDING TO MACROMOLECULES (NUCLEIC-ACIDS AND PROTEINS)

被引：8

作者：

STIBOROVA, M ^{[1
]}

ANZENBACHER, P ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST PHYSIOL, CS-14220 PRAGUE 4, CZECHOSLOVAKIA

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1992年 / 57卷 / 07期

关键词：

D O I：

10.1135/cccc19921537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) is oxidized by microsomal cytochromes P-450 to reactive metabolite(s) binding to macromolecules (nucleic acids, proteins) in vitro. The extent of binding to macromolecules proceeded in the order: protein > rRNA > tRNA > DNA. The pattern of products formed from Sudan I and binding of the reactive metabolites of this compound to macromolecules are dependent on the concentrations of Sudan I, NADPH and on the duration of the incubation. The participation of the adducts formed with macromolecules in the initiation of chemical carcinogenesis is discussed.

引用

页码：1537 / 1546

页数：10

共 16 条

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