USE OF PROPOFOL FOR THE PREVENTION OF CHEMOTHERAPY-INDUCED NAUSEA AND EMESIS IN ONCOLOGY PATIENTS

被引:41
作者
SCHER, CS [1 ]
AMAR, D [1 ]
MCDOWALL, RH [1 ]
BARST, SM [1 ]
机构
[1] CORNELL UNIV,MED CTR,COLL MED,NEW YORK,NY 10021
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1992年 / 39卷 / 02期
关键词
ANESTHETIC; INTRAVENOUS; PROPOFOL; VOMITING; ANTIEMETICS; INCIDENCE; NAUSEA;
D O I
10.1007/BF03008650
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Nausea and vomiting associated with antineoplastic chemotherapy are distressing and may keep patients from complying with chemotherapy protocols. No drug has emerged among many as an effective antiemetic. It has been speculated that propofol may have intrinsic antiemetic properties. We report the use of low-dose continuous infusion propofol in three oncology patients to treat chemotherapy-associated nausea and vomiting. A bolus of 0.1 mg.kg-1 followed by a continuous infusion of 1 mg.kg-1. hr-1 was effective in both prevention and treatment of nausea and vomiting. All three patients were alert, reported low nausea scores by visual analogue scale, and had no episodes of vomiting. When the infusion was discontinued, nausea and vomiting were noted in two patients, Propofol, given in a subanaesthetic infusion, was safe and effective as an antiemetic in these three patients.
引用
收藏
页码:170 / 172
页数:3
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