PLASMODIUM-VINCKEI-PETTERI - IDENTIFICATION OF THE STAGES SENSITIVE TO ARTEETHER

被引:28
作者
CAILLARD, V [1 ]
BEAUTELAFITTE, A [1 ]
CHABAUD, AG [1 ]
LANDAU, I [1 ]
机构
[1] EPHE,PROTOZOOL & PARASITOL COMPAREE LAB,F-75231 PARIS 05,FRANCE
关键词
PLASMODIUM-VINCKEI-PETTERI; RODENT MALARIA; CHRONOTHERAPY; SENSITIVE BLOOD STAGES; ARTEETHER; DRUG; SCHIZOGONIC RHYTHMS;
D O I
10.1016/0014-4894(92)90258-C
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Antimalarial activity of arteether, a derivative of artemisinin (qinghaosu) against blood-induced infections of the highly synchronous Plasmodium vinckei petteri rodent species of malaria was evaluated in Swiss mice. A single subcurative dose of arteether of 2.2 mg/kg body weight was injected subcutaneously to mice, either during the prepatent period or during the patent infection, when different stages of the parasitic cycle were present in the blood. It was shown that rings and young trophozoites were the most susceptible stages to arteether. The drug had no effect on merozoites and little effect on mid-term trophozoites which is the stage most sensitive to chloroquine. The alcoholic solution (10% alcohol in sterile water) had an immediate effect while the oily solution (miglyol 840) was active between 3 and 21 hr after injection. © 1992.
引用
收藏
页码:449 / 456
页数:8
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