MULTIPLE-DRUG-RESISTANT MUTANTS OF FELINE IMMUNODEFICIENCY VIRUS SELECTED WITH 2',3'-DIDEOXYINOSINE ALONE AND IN COMBINATION WITH 3'-AZIDO-3'-DEOXYTHYMIDINE

被引：13

作者：

GOBERT, JM ^{[1
]}

REMINGTON, KM ^{[1
]}

ZHU, YA ^{[1
]}

NORTH, TW ^{[1
]}

机构：

[1] UNIV MONTANA,DIV BIOL SCI,MISSOULA,MT 59812

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 04期

关键词：

D O I：

10.1128/AAC.38.4.861

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 muM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI. Interestingly, the AIR mutants were cross-resistant to phosphonoformate (PFA) and were hypersensitive to 2',3'-dideoxycytidine (ddC). Mutants of FIV were also selected in the presence of 10 muM ddI alone (DIS-1, DIS-2c), and these displayed a two- to fourfold decrease in susceptibility to ddI. Like the mutants selected with the combination of AZT plus ddI, DIS-1 and DIS-2c were cross-resistant to PFA and were hypersensitive to ddC. However, they remained as susceptible as wild-type FIV to AZT. Thus, the mutants selected with the combination of AZT plus ddI have phenotypes which reflect those obtained by selection with these drugs individually.

引用

页码：861 / 864

页数：4

共 21 条

[1] IMMUNOLOGICAL ABNORMALITIES IN PATHOGEN-FREE CATS EXPERIMENTALLY INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS [J].