OPIOID-RECEPTOR MESSENGER-RNA EXPRESSION IN THE RAT CNS - ANATOMICAL AND FUNCTIONAL IMPLICATIONS

被引：1039

作者：

MANSOUR, A ^{[1
]}

FOX, CA ^{[1
]}

AKIL, H ^{[1
]}

WATSON, SJ ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT PSYCHIAT,ANN ARBOR,MI

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 01期

关键词：

D O I：

10.1016/0166-2236(95)93946-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cloning of the opioid receptors has profoundly affected our understanding of opioid-receptor expression, regulation and function. This review focuses on the impact that cloning has had on our understanding of opioid-receptor anatomy, and provides broad anatomical maps of the three opioid-receptor mRNAs in relation to their binding sites. In addition, three model anatomical systems, the nigrostriatal and mesolimbic dopamine systems, the hypothalamic neuroendocrine axes, and the ascending and descending pain pathways, have been highlighted to discuss issues of receptor transport, trafficking and pre- versus postsynaptic localization.

引用

页码：22 / 29

页数：8

共 44 条

[1] EVIDENCE THAT THE AVERSIVE EFFECTS OF OPIOID ANTAGONISTS AND KAPPA-AGONISTS ARE CENTRALLY MEDIATED [J].