4,5-DIHYDRO-3-(2-PYRAZINYL)NAPHTHO[1,2-C]PYRAZOLE - A POTENT AND SELECTIVE INHIBITOR OF STEROID-17-ALPHA-HYDROXYLASE-C17,20-LYASE (P450-17)

被引：27

作者：

HARTMANN, RW

WACHTER, GA

SERGEJEW, T

WURTZ, R

DUERKOP, J

机构：

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 7-8期

关键词：

SELECTIVE INHIBITION; STEROIDOGENIC P450 ENZYMES; 17-ALPHA-HYDROXYLASE-C17,2O-LYASE; PROSTATE CANCER; BENIGN PROSTATIC HYPERPLASIA;

D O I：

10.1002/ardp.19953280703

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：573 / 575

页数：3

共 28 条

[1] SELECTIVE RETENTION OF DIHYDROTESTO-STERONE BY PROSTATIC NUCLEI [J].

ANDERSON, KM ;

LIAO, S .

NATURE, 1968, 219 (5151) :277-&

[2] INHIBITION OF TESTICULAR 17-ALPHA-HYDROXYLASE AND 17,20-LYASE BUT NOT 3-BETA-HYDROXYSTEROID DEHYDROGENASE-ISOMERASE OR 17-BETA-HYDROXYSTEROID OXIDOREDUCTASE BY KETOCONAZOLE AND OTHER IMIDAZOLE DRUGS [J].

AYUB, M ;

LEVELL, MJ .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1987, 28 (05) :521-531

[3] PHARMACOLOGY OF NOVEL STEROIDAL INHIBITORS OF CYTOCHROME P450(17-ALPHA) (17-ALPHA-HYDROXYLASE C17-20 LYASE) [J].

BARRIE, SE ;

POTTER, GA ;

GODDARD, PM ;

HAYNES, BP ;

DOWSETT, M ;

JARMAN, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1994, 50 (5-6) :267-273

[4]

BARRIE SE, 1992, Patent No. 2253851

[5] NEW AROMATASE INHIBITORS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF PYRIDYL-SUBSTITUTED TETRALONE DERIVATIVES [J].

BAYER, H ;

BATZL, C ;

HARTMANN, RW ;

MANNSCHRECK, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) :2685-2691

[6] THE DEVELOPMENT OF HUMAN BENIGN PROSTATIC HYPERPLASIA WITH AGE [J].

BERRY, SJ ;

COFFEY, DS ;

WALSH, PC ;

EWING, LL .

JOURNAL OF UROLOGY, 1984, 132 (03) :474-479

[7] EFFECT OF FINASTERIDE, A 5-ALPHA-REDUCTASE INHIBITOR ON PROSTATE TISSUE ANDROGENS AND PROSTATE-SPECIFIC ANTIGEN [J].

GELLER, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 71 (06) :1552-1555

[8]

HABECK DA, 1974, Patent No. 2317716

[9]

HABECK DA, 1973, Patent No. 2249644

[10]

HALL F, 1963, ENDOCRINOLOGY, V73, P547

← 1 2 3 →