DISULFIDE PAIRINGS IN GEOGRAPHUTOXIN-I, A PEPTIDE NEUROTOXIN FROM CONUS-GEOGRAPHUS

被引：33

作者：

HIDAKA, Y ^{[1
]}

SATO, K ^{[1
]}

NAKAMURA, H ^{[1
]}

KOBAYASHI, J ^{[1
]}

OHIZUMI, Y ^{[1
]}

SHIMONISHI, Y ^{[1
]}

机构：

[1] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

来源：

FEBS LETTERS | 1990年 / 264卷 / 01期

关键词：

Disulfide pairing; Geographotoxin; Na[!sup]+[!/sup] channel; Synthesis;

D O I：

10.1016/0014-5793(90)80756-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three intramolecular disulfide linkages of geographutoxin I, a peptidic neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986-1994]. The disulfide bridges were found to be between Cys3 and Cys15, Cys4 and Cys20, and Cys10 and Cys21, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages. © 1990.

引用

页码：29 / 32

页数：4

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